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MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:
1. A 62-year-old man with newly diagnosed type 2 diabetes mellitus presented with weight loss and anaemia.
On examination, the only abnormalities were evidence of recent weight loss and a red-brown rash on his lower limbs. Urinalysis showed glucose 3+.
Investigations:
serum total bilirubin19 umol/L (1-22) serum aspartate aminotransferase26 U/L (1-31) serum alkaline phosphatase98 U/L (45-105) serum gamma glutamyl transferase26 U/L (<50)
plasma gastrin21 pmol/L (<55)
plasma glucagon246 pmol/L (<50)
plasma pancreatic polypeptide158 pmol/L (<300)
plasma vasoactive intestinal polypeptide12 pmol/L (<30)
chromogranin A214 U/L (<40)
serum thyroid-stimulating hormone4.9 mU/L (0.4-5.0)
serum free T49.1 pmol/L (10.0-22.0)
CT scan of abdomen2-cm mass in the tail of the pancreas
What is the most likely explanation for the rash?
A) necrolytic migratory erythema
B) necrobiosis lipoidica diabeticorum
C) acrodermatitis enteropathica
D) pellagra
E) cutaneous metastasis
2. A 32-year-old woman, with a 22-year history of type 1 diabetes mellitus, was seen in a pre-pregnancy diabetes clinic. She was a primigravida.
On examination, she had early background retinopathy, her blood pressure was 128/68 mmHg, and her body mass index was 29.7 kg/m2 (18-25).
Investigations:
haemoglobin A1c56 mmol/mol (20-42)
urinary albumin:creatinine ratio1.2 mg/mmol (<3.5)
Over the years her haemoglobin A1c concentration had varied between 58 and 69 mmol/mol. She had impaired awareness of hypoglycaemia and experienced approximately two severe hypoglycaemic events per year. She was worried about the risk of severe congenital malformations in her baby.
To what extent will the average risk of severe congenital malformation be increased in infants born to this mother with pregestational diabetes?
A) ten-fold
B) six-fold
C) two-fold
D) eight-fold
E) four-fold
3. An 18-year-old woman presented with a 2-month history of polyuria and polydipsia. She
had been previously fit and well with regular periods. She was not taking any contraception.
Investigations:
serum potassium5.2 mmol/L (3.5-4.9)
serum corrected calcium2.30 mmol/L (2.20-2.60)
serum cortisol (09.00 h)350 nmol/L (200-700)
She went on to have a water deprivation test, the results of which are detailed below.
time (h)serum osmolality (mosmol/kg)urine osmolality (mosmol/kg) normal: 278-300normal: 100-1000 08.3028952 11.3029282 14.30301153 15.30-172
She was then given intramuscular DDAVP@ 2 micrograms at 16.00 h.
time (h)serum osmolality (mosmol/kg)urine osmolality (mosmol/kg) normal: 278-300normal: 100-1000 16.3030017.30-530 18.30-532
Results from an MR scan of pituitary are shown (see image).
What is the most likely diagnosis?
A) autoimmune (lymphocytic) hypophysitis
B) Rathke's cleft cyst
C) craniopharyngioma
D) non-functioning pituitary adenoma
E) psychogenic polydipsia
4. A 52-year-old man, with a 20-year history of type 2 diabetes mellitus, had been treated with metformin and, for the previous 4 years, biphasic insulin aspart twice daily. He had recently started a new job that required him to drive a 7.5-tonne vehicle.
If he were to apply for a UK Class C1 driving licence, who should complete the application form with him?
A) diabetes specialist nurse in secondary care
B) occupational health physician
C) consultant physician specialising in diabetes
D) solicitor
E) general practitioner
5. A 48-year-old man was investigated for a 6-month history of tiredness. There was no other medical history and he was taking no medication.
Investigations:
estimated glomerular filtration rate (MDRD)36 mL/min/1.73 m2 (>60) serum corrected calcium2.25 mmol/L (2.20-2.60) serum phosphate1.1 mmol/L (0.8-1.4)
plasma parathyroid hormone8.1 pmol/L (0.9-5.4) serum 25-OH-cholecalciferol48 nmol/L (45-90)
What is the most important next step in management?
A) reassure and discharge from clinic
B) prescribe calcium and vitamin D supplements
C) reassure and repeat in 3 months
D) refer for parathyroidectomy
E) refer for nephrological advice
Solutions:
Question # 1 Answer: A | Question # 2 Answer: C | Question # 3 Answer: A | Question # 4 Answer: C | Question # 5 Answer: E |
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