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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. An obtunded 61-year-old Woman weighing 45 kg with Worsening renal function is admitted to the hospital. She has a recent history of several days of nausea, fatigue, pruritus, and a metallic taste in her mouth. Her medical history includes diabetes, heart failure, and COPD. Admission laboratory values include:
SERUM CHEMISTRY
Sodium: 135 mEq/L
Potassium: 5.7 mEq/L
Chloride: 100 mEq/L
HCO3: 15 mEq/L
BUN: 96 mg/dL
Creatinine: 5.5 mg/dL
Glucose: 300 mg/dL
Calcium: 7.4 mg/dL
Serum ketones: Negative
ABGS (Room Air)
pH: 72
PaCO2: 30 mm Hg
PaO2: 75 mm Hg
O2 Sat: 90%
Chest X-ray shows a flattened diaphragm. Current medications include furosemide, fluticasone salmeterol, and glipizide. Which acid-base disorder does this patient exhibit?

A) Metabolic acidosis secondary to furosemide use
B) Respiratory acidosis secondary to COPD
C) Metabolic acidosis secondary to end-stage renal disease
D) Metabolic acidosis secondary to diabetic ketoacidosis

2. A 72-year-old man has chronic insomnia that has not responded to measures to improve sleep hygiene. The patient is not depressed and has no other chronic health problems. It is determined that medication use will probably be necessary to manage the insomnia. What is the best initial recommendation for this patient?

A) Trazodone
B) Amitriptyline
C) Diphenhydramine
D) Alprazolam

3. An oncology team that includes a pharmacotherapy specialist wishes to test the anecdotal observation that gabapentin reduces vincristine-induced neuropathic pain. Which of the following study designs would provide the best evidence for using gabapentin for this indication?

A) A case-control study of patients receiving Vincristine conducted in multiple centers.
B) A nonrandomized, open-label study of patients receiving vincristine with or without concomitant gabapentin.
C) A retrospective chart review using pharmacy records to determine which patients received Vincristine concomitantly with gabapentin.
D) A randomized, double-blind, placebo-controlled study of gabapentin administered concomitantly with Vincristine.

4. A 50-year-old woman experienced acute renal failure after receiving contrast dye for an imaging study. Her estimated creatinine clearance is now 20 mL/min. Her medications include:
* Piperacillin/tazobactam 4.5g intravenously every 8 hours
* Azithromycin 500 mg intravenously daily
* Famotidine 40 mg orally twice daily
* Enoxaparin 40 mg subcutaneously daily
* Metoprolol succinate 100 mg orally daily
Which drugs require dose reduction due to acute renal failure?

A) All of her current medications
B) Piperacillin/tazobactam, famotidine, and metoprolol succinate
C) Piperacillin/tazobactam, azithromycin, and enoxaparin
D) Piperacillin/tazobactam, famotidine, and enoxaparin

5. A pharmacotherapy specialist wishes to investigate the impact of thiazolidinedione therapy on Weight gain. The specialist will determine average body weight immediately before participants begin therapy with pioglitazone and again after they complete 12 weeks of treatment. Which of the following statistical methods is most appropriate for analyzing these data?

A) Unpaired t test
B) Paired t test
C) Fisher's exact test
D) Chi-square test

Solutions: